![]() ![]() "Our work further radicalizes this concept," Tuszynski said. "Only 20 years ago, we were thinking of the adult brain as static, terminally differentiated, fully established and immutable."īut work by Fred "Rusty" Gage, PhD, president and a professor at the Salk Institute for Biological Studies and an adjunct professor at UC San Diego, and others found that new brain cells are continually produced in the hippocampus and subventricular zone, replenishing these brain regions throughout life. "Who would have thought," said Tuszynski. Using a mouse model, Tuszynski and colleagues discovered that after injury, mature neurons in adult brains revert back to an embryonic state. This gives us fundamental insight into how, at a transcriptional level, regeneration happens," said senior author Mark Tuszynski, MD, PhD, professor of neuroscience and director of the Translational Neuroscience Institute at UC San Diego School of Medicine. "Using the incredible tools of modern neuroscience, molecular genetics, virology and computational power, we were able for the first time to identify how the entire set of genes in an adult brain cell resets itself in order to regenerate. ![]() The new study lays out a "transcriptional roadmap of regeneration in the adult brain." Until relatively recently, it seemed an impossible task. Repairing damage to the brain and spinal cord may be medical science's most daunting challenge. ![]()
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